Overcoming natural constraints to develop new vancomycin-type antibiotics

Monash University

AMR bacteria are developing increased resistance to glycopeptide antibiotics (such as vancomycin) –which are last-resort antibiotics used in the clinic to treat serious Gram-positive bacterial infections.

We are utilising a new chemo-enzymatic formation route that we have pioneered to generate and explore the properties of new vancomycin derivatives. This will allow us to explore the structure/function relationships of these crucial antibiotics and to overcome growing bacterial resistance against these compounds.